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The IPCCSB research programs are strongly supported by dedicated infrastructure developments and core facilities in the Harvard community, such as the automated cryo-electron microscope FEI Tecnai Arctica at the Harvard Center for Nanoscale Systems (CNS) and the Sullivan supercomputer at the Intel® PCCSB that is powered by the advanced Intel® Many Integrated Core architecture. Building on major developments in cryo-electron microscopy and computer technology, the research programs at the Intel® PCCSB are expected to expand the horizon of quantitative approaches that will transform life sciences and molecular medicine.