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The research at Intel® Parallel Computing Center for Structural Biology (Intel® PCCSB) aims to develop cutting-edge solutions for the next-generation high-performance computing platform for structural biology and systems biology, largely based on Intel® Many Integrated Core (MIC) architecture. The core research mission at Intel® PCCSB focuses on a major computational challenge in modern life sciences, i.e., visualizing biological molecules in action at atomic resolution by single-molecule electron microscopy and related nanotechnology. The research team in the Intel® PCCSB capitalizes on a wide spectrum of expertise, from software engineering, high-performance computing, biophysics, molecular biology, systems biology, virology and immunology, a comprehensive blend of computer engineering and life sciences. We seek to capitalize on the tremendous potential of Intel® MIC architecture, as well as heterogeneous parallel computing, to advance our capability to process a rapidly increasing volume of cryo-electron microscopy data that “encrypts” the fundamental structural “codes” of life.

The research at the Intel®PCCSB is vibrant, ranging from applied computer sciences to various branches in quantitative biology and molecular medicine. The areas of research emphesis at the Intel® PCCSB include: machine learning and artificial intelligence, high-performance computing algorithms, biomolecular complex dynamics, structural systems biology, structure-inspired bioengineering, structure-based vaccine and drug discovery. The IPCCSB and Harvard Center for Nanoscale Systems collaborate on the high-performance operation of Laboratory for Cryo-Electron Microscopy (LCM). LCM is a cradle of next-generation scientists who possess comprehensive expertise in both computer sciences and life sciences.