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Recent Publications

Y. Zhu, W.L. Wang, D. Yu, Q. Ouyang, Y. Lu, Y. Mao. Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nature Commun. 9, 1360 (2018). Download

Y. Dong, S. Chen, S. Zhang, J. Sodroski, Z. Yang, D. Liu, Y. Mao. Folding DNA into a lipid-conjugated nanobarrel for controlled reconstitution of membrane proteins. Angew. Chem. Int. Ed. 57, 2072-2076 (2018). Download

J. Wu, Y. Ma, C. Congdon, B. Brett, S. Chen, Q. Ouyang, Y. Mao. Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning. PLoS ONE 12, e0182130 (2017). https://doi.org/10.1371/ journal.pone.0182130. arXiv: 1604.04539. Download

Y. Zhu, Q. Ouyang, Y. Mao. A deep convolutional neural network approach to single-particle recognition in cryo-electron microscopy. BMC Bioinformatics 18, 348 (2017). arXiv: 1605.05543. Download

Y. Lu, J. Wu, Y. Dong, S. Chen, S. Sun, Y.B. Ma, Q. Ouyang, D.J. Finley, M.W. Kirschner, Y. Mao. Conformational landscape of the p28-bound human proteasome regulatory particle. Molecular Cell 67, 322-333.e6 (2017). Download

H. Sharif, L. Yang, Y. Dong, L. Dong, W.L. Wang, Y. Mao, H. Wu. Cryo-EM structure of the DNA-PK holoenzyme. Proc. Natl. Acad. Sci. USA 114, 7367-7372 (2017). Download

S. Chen, J. Wu, Y. Lu, Y.B. Ma, B.H. Lee, Z. Yu, Q. Ouyang, D.J. Finley, M.W. Kirschner, Y. Mao. Structural basis for dynamic regulation of the human 26S proteasome. Proc. Natl. Acad. Sci. USA 113, 12991-12996 (2016). Download

Y. Xu, J. Wu, C.C. Yin, Y. Mao. Unsupervised cryo-EM data clustering through adaptively constrained K-means algorithm. PLoS ONE 11, e0167765 (2016). doi: 10.1371/journal.pone.0167765. arXiv: 1609.02213. Download

A. Lu, Y. Li, F.I. Schmidt, Q. Yin, S. Chen, T.M. Fu, A.B. Tong, Y. Mao, H. Wu. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nature Struct. Mol. Biol. 23, 416-425 (2016). Download

L. Zhang, S. Chen, J. Ruan, J. Wu, A.B. Tong, Q. Yin, Y. Li, L. David, A. Lu, W.L. Wang, C. Marks, Q. Ouyang, X. Zhang, Y. Mao*, H. Wu*. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350, 404-409 (2015). Download