Machine Learning

Structural heterogeneity in single-particle images presents a major challenge for high-resolution cryo-electron microscopy (cryo-EM) structure determination. We recently developed a statistical manifold learning approach for unsupervised single-particle deep classification. When optimized for Intel high-performance computing ...... Read more

Assembling the Wheel of Death

Inflammation is an essential defense strategy mounted by the innate immune system to eradicate infections and repair tissue damage. The inflammasome is an intracellular signaling complex involved in inflammation initiation and perpetuation. These multimeric protein assemblies promote the activation of proteases and ...... Read more